Is it that athletes suddenly became stupid and were
caught using Meldonium? We have always
say that we do not need doping if we follow an orderly life considering
nutrition, recovery and training. But
most of our athletes are not educated well to follow a life for success.
We have posted an article related to genes and
training. The use of meldonium reminds
me of patients addicted to heroin whom I used to detoxify, they continue to
have bone pain for several months after stopping heroin, even when they were
getting substitutes. The up-and-down-regulation
after inducing genes takes months to come back to normal, reason why athletes
using meldonium could not go “cold turkey” after January first of 2016.
Up-regulation is a process that occurs within a cell
triggered by a signal (originating internal or external to the cell), which
results in increased expression of one or more genes and as a result the
protein(s) encoded by those genes. On the converse, down-regulation is a process
resulting in decreased gene and corresponding protein expression.
·
Up-regulation occurs, for example, when a cell is
deficient in some kind of receptor. In this case, more receptor protein is
synthesized and transported to the membrane of the cell and, thus, the
sensitivity of the cell is brought back to normal, reestablishing homeostasis.
·
Down-regulation occurs, for example, when a cell is
overstimulated by a neurotransmitter, hormone, or drug for a
prolonged period of time, and the expression of the receptor protein is
decreased in order to protect the cell (see also tachyphylaxis).
5 août 2012
Inducing
Genes versus Maximizing Gene Expression
Wiggins wins the time trial at the London
Olympics. At the age of 20 he was winning in the track, where the
only way to increase velocity is by increasing cadence. Wiggins
transformed himself genetically by inducing genes that
could help pedaling at high cadence; he just needed time on the bike to win the
Tour the France. At the same time, he was learning more about the
peloton. The next step was to maximize the gene
induction that he had produced while practicing cadence on the
track; and this is done with long hours on the road keeping what was induced
manifested through technique and cadence. Inducing genes is the job to
accomplish before the age of 20 if you want to be like Wiggins.
Gene induction is the job done with Armstrong
as pointed out by Edward Coyle and it is translated as PEDALING EFFICIENCY.
Although during all laboratory measures of
mechanical efficiency, cycling cadence was held constant at 85 rpm, this
individual’s freely chosen cycling cadence during time trial racing of 30- to
60-min duration increased progressively during this 7-yr period from 85–95 rpm
to 105–110 rpm. This increase in freely chosen revolutions per minute when cycling
at high intensity is indeed consistent with increases in type I muscle fibers
because cyclists with a higher percentage of type I fibers choose a higher
pedaling cadence when exercising at high power outputs (22). Although this may
initially seem paradoxical, higher cycling cadence serves to both bring muscle
fiber contraction velocity closer to that of maximum power and reduce the
muscle and pedaling force required for each cycling stroke. Keep in mind that
when exercising at a given rate of oxidative metabolism, an 8% increase in
mechanical efficiency will result in 8% more muscle power and force development
on the pedals when cycling cadence is held constant. As cycling efficiency
increases due to increased percentage of type I muscle fibers, it is possible
that increased power is manifested by increasing cycling cadence (i.e.,
velocity) rather than increasing the muscle forces directed to the pedals. This
approach appears to produce less sensation of effort relative to muscular
strength (27). Therefore, it is likely that the increases in freely chosen
cycling cadence displayed over the years by this Tour de France champion
reflect his increased mechanical efficiency, agreeing with the pattern expected
to result from muscle fiber conversion from type II to type I.
Nowadays is
not enough maximizing genes; we need to induce genes in order to maximize
performance. Translated differently what I said, do not expect to have an
athlete with the full speed and just add mileage after DISCOVERING HIM or
HER. You have to INDUCE THE GOING FAST GENES by
increasing cadence and improving technique. Guennadi Tourestki puts
it more elegantly: “10,000 hours in the water are needed to discover talent.”
And for that same reason, PLEASE EDUCATED THE KID first to be able to induce
genes. Wiggins could improve from what we see from his interview;
fortunately, he got the genes induced on time or after a break from his self.
